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- Title
Fibronectin peptide induces apoptosis on adherent and spreading hemocytes of the giant Pacific oyster Crassostrea gigas.
- Authors
Terahara, Kazutaka; Takahashi, Keisuke G.; Mori, Katsuyoshi
- Abstract
For molluscs, including bivalves, circulating hemocytes serve an important role in the principal mechanisms of the host defense. The hemocyte adherence and mobility are essential factors in processes such as phagocytosis against foreign particles and migration toward inflammatory sites. It is described in crustaceans that these immune responses dependent on hemocyte adherence are mediated by the membrane receptor, such as integrins. In this article, the article authors demonstrated that the RGD peptide treatment resulted in the C. gigas hemocyte apoptosis that was induced irrespective of whether the hemocyte integrin is activated and bound to the plasma. This result indicates that the apoptosis induction by the RGD peptide in the C. gigas hemocytes was a different mechanism from that of the anchorage-dependent cells.
- Subjects
BLOOD cells; IMMUNE response; FIBRONECTINS; PACIFIC oysters; PHAGOCYTOSIS; CRUSTACEA; INTEGRINS; BIVALVES
- Publication
Fisheries Science, 2004, Vol 70, Issue 4, p719
- ISSN
0919-9268
- Publication type
Article
- DOI
10.1111/j.1444-2906.2004.00864.x