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- Title
Toxicometabolomics: Identification of markers of chronic exposure to low doses of aliphatic hydrocarbons.
- Authors
Ukolov, A.; Kessenikh, E.; Radilov, A.; Goncharov, N.
- Abstract
The metabolic profile of plasma of white non-linear rats was investigated under normal conditions and after chronic inhalation exposure to low doses of aliphatic hydrocarbons (HC) with the number of carbon atoms from 6 to 10. The metabolic profile was determined by a combination of gas chromatography/mass spectrometry and high-performance liquid chromatography/high-resolution mass spectrometry with the subsequent use of chemometrical methods for data treatment and presentation. It was shown that continuous 90-day exposure to a mixture of C-C saturated hydrocarbons at a concentration of 160 ± 20.5 mg/m leads to various metabolic impairments in the liver and kidneys. Exposure to hydrocarbon mixtures at doses of 31.4 ± 5.6 and 5.2 ± 1.8 mg/m evoked significantly smaller changes. Novel metabolic markers of the toxic effect of low concentrations of C6-C10 aliphatic hydrocarbons were revealed. The concentration ratio of pyrophosphoric and oxalic acids in rat blood plasma was found to be the most sensitive marker called a pyrophosphate index. A hypothesis was proposed about the disturbance of the redox balance as a leading pathogenetic mechanism of neuropathies and concomitant pathologies associated with chronic HC intoxication.
- Subjects
ALIPHATIC hydrocarbons; TOXICOLOGY of poisonous gases; DRUG dosage; GAS chromatography; PYROPHOSPHATES
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2017, Vol 53, Issue 1, p25
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093017010033