We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ASSESSMENT OF THE IMPACT OF THE EGYVIR ON RATS EXPERIMENTAL ANIMALS; A PRECLINICAL STUDY FOR SARS-COV-2 TREATMENT.
- Authors
Roshdy, Wael H.; Abdelhameed, Mohamed F.; Rashed, Helmy A.; Abdellateif, Mona S.; Salamony, Azza; Abd El-Rahman, Sahar S.; Shaarawy, Sabry
- Abstract
Background: The SARS-COV-2 is a worldwide pandemic problem. We developed a herbal extract with potent in-vitro virucidal, antiinflammatory and immunomodulatory effects called EGIVIR. Our aim is to assess the bioavailability and cytotoxicity of EGYVIR on different organs and biological systems in Sprague Dawley rats as a model of experimental animals. Methods: 128 rats were divided into 16 groups (8 rats each), where Egyvir was assessed in oral doses of 20, 30, and 40 mg/kg body weight, and by inhalation in 0.2, 0.3, and 0.4 mg/kg body weight, four times/day, compared to the control groups. Results: The Egyvir had no significant effect on the blood pressure, pulse, motor activity, histological, hematological, and coagulation profiles. Also, the blood levels of triglycerides, cholesterol, blood glucose, lactate dehydrogenase (LDH), and creatine phosphor kinase (CPK) were not significantly affected. Egyvir had no harmful effect on the kidney and liver functions, blood electrolytes levels and urinary levels of sodium, potassium, and chloride. There was no significant effect on the serum levels of interleukin-1β (IL-1β), IL-2, IL-4, IL-6, IL-10, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). Additionally, there was no significant change in the levels of Superoxide dismutase (SOD), catalase, reduced glutathione (GSH), and malonaldehyde (MDA) in comparison to the control groups (P<0.05). Conclusion: Egyvir is considered a safe antiviral natural drug. It could be used for the treatment of SARS-COV-2 without any adverse effects when used with the recommended doses. However, these data are a preliminary step for validation in a clinical setting.
- Subjects
LABORATORY animals; SARS-CoV-2; SPRAGUE Dawley rats; BIOAVAILABILITY; BIOLOGICAL systems; LACTATE dehydrogenase
- Publication
Journal of Microbiology, Biotechnology & Food Sciences, 2023, Vol 13, Issue 1, p1
- ISSN
1338-5178
- Publication type
Article
- DOI
10.55251/jmbfs.9658