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- Title
Piperidine-Promoted Three-Component Condensation: Synthesis of Chromene Heterocycles and Pyrazolotriazoles.
- Authors
Kangani, Mehrnoush; Hazeri, Nourallah; Yazdani ‐ Elah ‐ Abadi, Afshin; Maghsoodlou, Malek ‐ Taher
- Abstract
Chromenes, the oxygen-containing heterocyclic compounds, have a 'special' place in biologically active natural products and in synthetic chemistry and in the fields of medicinal, agrochemical, cosmetic, and pigment industries. In this work, piperidine was used as a base catalyst for the convenient synthesis of 1,4-dihydropyrano[2,3- c]pyrazole, 5,10-dihydro-4 H-benzo[ g]chromene, and pyrazolo[1,2- a] [1,2,4]triazole derivatives at ambient temperature. This methodology has several advantages including the use of easily accessible and inexpensive catalysts, short reaction times, high yields, convenient work-up, and not needing column chromatography.
- Subjects
HETEROCYCLIC compounds synthesis; PYRAZOLES; ORGANIC synthesis; ANTI-infective agents; CHEMICAL reactions; CHEMICAL derivatives; COLUMN chromatography
- Publication
Journal of the Chinese Chemical Society, 2017, Vol 64, Issue 11, p1259
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201700074