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- Title
Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain.
- Authors
Vela, Ana Isabel; Villalón, Pilar; Sáez-Nieto, Juan Antonio; Chacón, Gema; Domínguez, Lucas; Fernández-Garayzábal, José Francisco
- Abstract
Streptococcus pyogenes appears to be almost exclusively restricted to humans, with few reports on isolation from animals. We provide a detailed characterization (emm typing, pulsed-field gel electrophoresis [PFGE], and multilocus sequence typing [MLST]) of 15 S. pyogenes isolates from animals associated with different clinical backgrounds. We also investigated erythromycin resistance mechanisms and phenotypes and virulence genes. We observed 2 emm types: emm12 (11 isolates) and emm77 (4 isolates). Similarly, we observed 2 genetic linages, sequence type (ST) 26 and ST63. Most isolates exhibited the M macrolide resistance phenotype and the mefA/ermB genotype. Isolates were grouped into 2 clones on the basis of emm-MLST-PFGE-virulence gene profile combinations: clone 1, characterized by the combined genotype emm12-ST36-pulsotype A-speG; and clone 2, characterized by the genotype emm77-ST63-pulsotype B-speC. Our results do not show conclusively that animals may represent a new reservoir of S. pyogenes but indicate the ability of human-derived S. pyogenes isolates to colonize and infect animals.
- Subjects
STREPTOCOCCUS pyogenes; VETERINARY clinical biochemistry; PULSED-field gel electrophoresis; ERYTHROMYCIN; MICROBIAL virulence genetics
- Publication
Emerging Infectious Diseases, 2017, Vol 23, Issue 12, p2011
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2312.151146