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- Title
Angelica gigas Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL/KsJ- db/db Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway.
- Authors
Bae, Ui-Jin; Choi, Eun-Kyung; Oh, Mi-Ra; Jung, Su-Jin; Park, Joon; Jung, Tae-Sung; Park, Tae-Sun; Chae, Soo-Wan; Park, Byung-Hyun
- Abstract
The prevention and management of type 2 diabetes mellitus has become a major global public health challenge. Decursin, an active compound of Angelica gigas Nakai roots, was recently reported to have a glucose-lowering activity. However, the antidiabetic effect of Angelica gigas Nakai extract (AGNE) has not yet been investigated. We evaluated the effects of AGNE on glucose homeostasis in type 2 diabetic mice and investigated the underlying mechanism by which AGNE acts. Male C57BL/KsJ- db/db mice were treated with either AGNE (10 mg/kg, 20 mg/kg, and 40 mg/kg) or metformin (100 mg/kg) for 8 weeks. AGNE supplementation (20 and 40 mg/kg) significantly decreased fasting glucose and insulin levels, decreased the areas under the curve of glucose in oral glucose tolerance and insulin tolerance tests, and improved homeostatic model assessment-insulin resistant (HOMA-IR) scores. AGNE also ameliorated hepatic steatosis, hyperlipidemia, and hypercholesterolemia. Mechanistic studies suggested that the glucose-lowering effect of AGNE was mediated by the activation of AMP activated protein kinase, Akt, and glycogen synthase kinase-3. AGNE can potentially improve hyperglycemia and hepatic steatosis in patients with type 2 diabetes.
- Subjects
ADENOSINE monophosphate; ANALYSIS of variance; ANGELICA (Plants); ANIMAL experimentation; BLOOD sugar; CELLULAR signal transduction; FATTY liver; FISHER exact test; GLUCOSE tolerance tests; HYPERGLYCEMIA; MICE; PROBABILITY theory; PROTEIN kinases; RESEARCH funding; STATISTICS; WESTERN immunoblotting; DATA analysis; TREATMENT effectiveness; DATA analysis software; SIGNAL peptides
- Publication
American Journal of Chinese Medicine, 2016, Vol 44, Issue 8, p1627
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X16500919