We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats.
- Authors
Salau, Veronica F.; Erukainure, Ochuko L.; Olofinsan, Kolawole A.; Msomi, Nontokozo Z.; Ijomone, Olayemi K.; Islam, Md. Shahidul
- Abstract
Cardiovascular abnormalities have been reported as a major contributor of diabetic mortality. The protective effect of ferulic acid on diabetic cardiomyopathy in fructose‐streptozotocin induced type 2 diabetes (T2D) rat model was elucidated in this study. Type 2 diabetic rats were treated by oral administration of low (150 mg/kg b.w) and high (300 mg/kg b.w) doses of ferulic acid. Metformin was used as the antidiabetic drug. Rats were humanely euthanized after 5 weeks of treatment, and their blood and hearts were collected. Induction of T2D depleted the levels of reduced glutathione, glycogen, and HDL‐cholesterol and the activities of superoxide dismutase, catalase, ENTPDase, and 5′nucleotidase. It simultaneously triggered increase in the levels of malondialdehyde, total cholesterol, triglyceride, LDL‐cholesterol, creatinine kinase‐MB as well as activities of acetylcholinesterase, angiotensin converting enzyme (ACE), ATPase, glucose‐6‐phopsphatase, fructose‐1,6‐bisphophatase, glycogen phosphorylase, and lipase. T2D induction further revealed an obvious degeneration of cardiac muscle morphology. However, treatment with ferulic acid markedly reversed the levels and activities of these biomarkers with concomitant improvement in myocardium structural morphology, which had favorable comparison with the standard drug, metformin. Additionally, T2D induction led to the depletion of 40%, 75%, and 33% of fatty acids, fatty esters, and steroids, respectively, with concomitant generation of eicosenoic acid, gamolenic acid, and vitamin E. Ferulic acid treatment restored eicosanoic acid, 2‐hydroxyethyl ester, with concomitant generation of 6‐octadecenoic acid, (Z)‐, cis‐11‐eicosenoic acid, tridecanedioic acid, octadecanoic acid, 2‐hydroxyethyl ester, ethyl 3‐hydroxytridecanoate, dipalmitin, cholesterol isocaproate, cholest‐5‐ene, 3‐(1‐oxobuthoxy)‐, cholesta‐3,5‐diene. These results suggest the cardioprotective potential of ferulic acid against diabetic cardiomyopathy.
- Subjects
FERULIC acid; DIABETIC cardiomyopathy; ANGIOTENSIN converting enzyme; EICOSANOIC acid; GLYCOGEN phosphorylase; ORAL drug administration
- Publication
Fundamental & Clinical Pharmacology, 2023, Vol 37, Issue 1, p44
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/fcp.12819