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- Title
Effect of Regular Exercise and DL-a-Upoic Acid Supplementation on BDNF, Caspase-3 Proteins and Apoptosis in Aging-Induced Rate Hippocampus.
- Authors
Chang-Hun Chae; Park, Sok
- Abstract
We investigated the combined effects of 8-week exercise training and DL-a-lipoic acid supplementation on biochemical markers of MDA, BDNF, Caspase-3 and apoptosis in hippocampus of aging rats induced by D-galactose injection (50 mg/kg dissolved in 0.1 ml dilution water). The rats were randomly assigned to one of the following four groups (n=8 per group): 1) control group (A-con) 2) exercise training group (A-ex) 3) DL-a-lipoic acid supplementation group (A-ala) 4) exercise training with DL-a-lipoic acid supplementation group (A-ea). The exercise training program regimen consisted of running on a treadmill at an increasing pace. DL-a -lipoic acid (100 mg/kg) was supplemented orally every day for 8 weeks. MDA concentrations were significantly lower in the A-ex, A-ala, A-ea groups compared with A-con group. BDNF protein was significantly higher in the A-ex, A-ala, A-ea groups compared with A-con group. Caspase-3 protein was significantly lower in the A-ex, A-ala, A-ca groups compared with A-con group. In addition, apoptotic cell death was significantly lower in the A-ex, A-ala, A-ea groups compared with A-con group. These results suggest that regular exercise training with DL-a-lipoic acid supplementation can offer beneficial effects of preventing the aging and damaging of hippocampal neurons, which contributes to oxidative stress and apoptosis in D-galactose-induced aging rats.
- Subjects
OXIDATIVE stress; OXIDATION-reduction reaction; PHYSIOLOGICAL stress; CELL death; AGING; APOPTOSIS; RUNNING; BIOCHEMISTRY; NEURONS
- Publication
International Journal of Applied Sports Sciences, 2008, Vol 20, Issue 2, p78
- ISSN
1598-2939
- Publication type
Article