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- Title
Editorial: Angiogenesis and access to vasculature as a target in gastrointestinal tumors and predictive biomarkers identification: an open challenge.
- Authors
Lai, Eleonora; Ziranu, Pina; Pezzella, Francesco; Pretta, Andrea; Liscia, Nicole; Zhiwei Hu
- Abstract
This document is an editorial published in Frontiers in Oncology titled "Angiogenesis and access to vasculature as a target in gastrointestinal tumors and predictive biomarkers identification: an open challenge." The editorial discusses the importance of tumor angiogenesis in gastrointestinal cancers and the need for predictive biomarkers to improve patient selection for anti-angiogenic treatments. It highlights the current lack of validated clinical/translational predictive factors and the ongoing research efforts to identify reliable markers. The editorial also provides a summary of the articles included in the research topic, which cover topics such as the role of insulin-like growth factor-II mRNA-binding protein 3 (IGF2BP3) in gastric cancer, the involvement of angiogenins in tumor angiogenesis, the crosstalk between innate immunity and endothelial cells in tumor angiogenesis regulation, and the potential of anti-angiogenic treatment combined with immunotherapy in colorectal and gastric cancer patients. The authors express their gratitude to the contributing authors and emphasize the importance of further investigation in this field to identify new therapeutic targets and predictive factors for anti-angiogenic treatment response.
- Subjects
GASTROINTESTINAL tumors; TUMOR markers; NEOVASCULARIZATION; BLOOD vessels
- Publication
Frontiers in Oncology, 2024, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2024.1428174