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- Title
Cascade Synthesis of 1,4-Butanediol Monomesylate Glycoconjugates: Anticancer Candidates for Leukemia.
- Authors
Rashidnejad, Hamid; Kordi, Mohammad Anvar; Pesyan, Nader Noroozi; Allahyari-devin, Maryam; Frashchi, Alireza Hajabbas; Ramezanitaghartapeh, Mohammad
- Abstract
Acascade synthesis protocol for glycosides of 1,4-butanediol monomesylate, as anticancer drug candidates, is proposed. All obtained compounds are characterized by FT-IR, 1H and 13C NMR spectroscopy technique after separation by column chromatography. Cytotoxicity of the obtained glucosides and galactosides of 1,4-butanediol monomesylate on K562 human erythroleukemia cell line and normal peripheral blood mononuclear cells (PBMCs) is also investigated. Compared to the commercial anticancer drugs such as busulfan and doxorubicin, these compounds indicate promising results against the test cells. It is suggested that these new anticancer agents can be a potential replacement for the current drugs since they have relatively convenient synthetic procedure and higher effectiveness.
- Subjects
GLYCOCONJUGATES; MONONUCLEAR leukocytes; BUTANEDIOL; NUCLEAR magnetic resonance spectroscopy; GALACTOSIDES
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 55, Issue 11, p1177
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02555-9