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- Title
Analgesic activity of Psidium guajava (L.) fruit extracts effect in mice.
- Authors
Prajapati, Sonu; Patel, Vijay; Mukherjee, Jayanti
- Abstract
The unrivalled substitutes to synthetic medicines are available, for relieving pain and these substitutes are from natural products of plants. They exhibit variety of activities. The present study evaluated the analgesic activity of the Aqueous fruit extract of the plant. The Aqueous extract of the fruits of P. guajava were tested in three pain models viz. to viz. Eddy's Hot plate, Tail immersion and Acetic acid induced pain models in mice. The treatment of P. guajava at varying doses (100 mg/kg and 200 mg/kg) of extract was administered orally by gastric gavage. It significantly (P<0.05) reduced the pain induced by Hot plate (74.29%) Tail immersion (76.03%) and Acetic acid induced abdominal contraction (73.92%) respectively and potency found was equivalent as compared to standard drug Diclofenac sodium and Pentazocin. The presence of flavonoids, tanins and saponins in the extract of P. guajava are responsible for Analgesic effect.
- Subjects
FRUIT extracts; GUAVA; PLANT products; ACETIC acid; NATURAL products; PLANT extracts
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 6, p6659
- ISSN
0976-7126
- Publication type
Article