We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
POST- TRAUMATIC BONE REPAIR AND ANTIINFLAMMATORY DRUGS--SAIDs, NSAIDs.
- Authors
Hussar, Piret; Haviko, Tiit; Hussar, Ülo
- Abstract
The comparison of the effect of steroid and non-steroid inflammatory drugs on the post-traumatic bone repair in rats was carried out. We studied the effects of two steroid antiinflammatory drugs (SAIDs) on post-traumatic bone healing (perforation) in rats: synthetic SAID dexamethasone (0,4 mg/rat/day for the 1st, 4th and 7th day i. m.) and hydrocortisone (20 mg/rat once i. m.) and one of the nonsteroid antiinflammatory drugs (NSAID) diclofenac (2,5 mg/rat/day for 4 days i. m.). The animals were killed at the 1st, 4th, 7th, 14th and 35th day after bone perforation. Histological evaluation and computer morphometry were performed on the sections stained with routine methods (haematoxyline and eosin etc.). There is histological evidence of the delayed maturation of callus, of the inhibited mitotic activity of cells, the increased degranulation of mast cells (tissue basophils), as well as the increase of scarce nucleated giant cells after the dexamethasone administration (1-4 days). The inhibitory effect of hydrocortisone and diclofenac is flatter. SAIDs and NSAID effect on post-traumatic bone repair is reversible after the cessation of administration. According to the histological investigations, the drugs can be used as analgesics during the first postoperative week.
- Subjects
STEROIDS; NONSTEROIDAL anti-inflammatory agents; DRUG efficacy; HYDROCORTISONE; TREATMENT of fractures; CELL cycle; BONE growth
- Publication
Papers on Anthropology, 2004, Vol 13, p38
- ISSN
1406-0140
- Publication type
Article