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- Title
Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma.
- Authors
Chen, Yiwen; Zhou, Yuhang; Yan, Ziyang; Tong, Peilin; Xia, Qiang; He, Kang
- Abstract
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In recent years it has become increasingly evident that the tumor microenvironment (TME) plays an important role in tumor progression and metastasis. Tumor microenvironment (TME) refers to the complex tissue environment of tumor occurrence and development. Here, we summarize the development of HCC and the role of cellular and non-cellular components of the TME in the metastasis HCC, with particular reference to tumor-infiltrating immune cells. We also discuss some of the possible therapeutic targets for the TME and the future prospectives of this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the role of the infiltrating immune cells in TME in the metastasis of HCC and highlights the future outlook for targeted therapy of the TME in the context of recent experiments revealing a number of therapeutic targets targeting the TME.
- Subjects
TUMOR-infiltrating immune cells; TUMOR microenvironment; METASTASIS; HEPATOCELLULAR carcinoma; CANCER invasiveness
- Publication
Cellular Oncology (2211-3428), 2023, Vol 46, Issue 6, p1595
- ISSN
2211-3428
- Publication type
Article
- DOI
10.1007/s13402-023-00841-6