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- Title
The serological and biochemical markers of adrenal cortex and endocrine pancreas dysfunction in patients with Hashimoto's thyroiditis: A hospital based pilot study.
- Authors
Ambigapathy, Jayakumar Selvi; Sahoo, Jayaprakash; Kamalanathan, Sadishkumar; Negi, V. S.; Sridhar, M. G.; Kar, Sitanshu; Vivekanandan, Muthupillai
- Abstract
Aim: To assess the proportion of Addison's disease and type 1 diabetes mellitus in patients with Hashimoto's thyroiditis. Materials and Methods: The subjects with hypothyroidism due to Hashimoto's thyroiditis were included in this study over 2 years. Hypothyroidism was defined as high serum thyroid stimulating hormone (>5 mIU/l) with or without low serum thyroxine level. Hashimoto's thyroiditis was defined as patients having high TPO antibody titer (>40 IU/ ml). Autoimmune markers of Addison's disease and type 1 diabetes mellitus i.e. anti-adrenal (21-hydroxylase) antibody, anti-glutamic acid decarboxylase (GAD) antibody and islet antigen-2 (IA-2) antibody were measured among them. Additionally, 250 microgram ACTH stimulation test was done in subjects with positive anti-adrenal antibody. Similarly, beta cell function was assessed in patients with positive anti-GAD and/or anti-IA2 antibody. Results: Out of 150 subjects screened, 136 patients were included in this study. Seven subjects had positive anti-adrenal antibody while 15 had anti-IA2 antibodies. None had both anti-adrenal and anti-IA2 antibody. The anti-GAD antibody was not present in any of the subjects in the study. ACTH stimulation test was done in 4/7 subjects with positive antiadrenal antibody & beta cell function was assessed in 8/15 subjects with positive islet cell antibodies. Neither adrenal insufficiency nor impaired beta cell function was found in any of these subjects. Conclusions: Nearly one-sixth of subjects with hypothyroidism with Hashimoto's thyroiditis had either anti-adrenal or islet cell antibodies with normal adrenal and beta cell function.
- Subjects
ADRENAL cortex; AUTOIMMUNE thyroiditis; PILOT projects
- Publication
Indian Journal of Endocrinology & Metabolism, 2017, Vol 21, p21
- ISSN
2230-8210
- Publication type
Article