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- Title
Low-dose aspirin should be initiated for sickle cell patients.
- Authors
Helvaci, Mehmet Rami; Sahan, Mustafa; Bay, Feyyaz; Yildirim, Yasin; Dede, Guner; Cihangir, Emrullah; Mermer, Abdussamet; Pocock, Lesley
- Abstract
Background: We tried to understand whether or not there is an association between platelet (PLT) count of peripheric blood and severity of sickle cell diseases (SCDs). Methods: SCDs patients with red blood cell (RBC) transfusions of less than 50 units in their lives were put into the first and 50 units or higher were put into the second groups. Results: The study included 224 patients (70.8%) in the first and 92 patients (29.1%) in the second groups (p<0.001). Mean ages were similar in both groups (28.9 and 30.0 years, respectively, p>0.05). Male ratio was significantly higher in the second group (45.5% versus 64.1%, p<0.001). Although smoking was also higher in the second group (12.0% versus 17.3%, p>0.05), the difference was nonsignificant probably due to the small sample size of the second group. Mean units of transfused RBCs were 12.9 and 99.0 in the groups (p<0.000). Although white blood cell and PLT counts of peripheric blood were higher in the second group, the difference was only significant for the PLT counts (p= 0.005), probably due to the same reason above. Number of painful crises per year, digital clubbing, chronic obstructive pulmonary disease, leg ulcers, stroke, chronic renal disease, and coronary heart disease were higher in the second group, significantly (p<0.05 for all). Conclusion: SCDs are chronic inflammatory processes on endothelium mainly at the capillary level, and there was a highly significant association between PLT count and severity of the SCDs. So low-dose aspirin will probably be beneficial for patients with SCDs.
- Subjects
SICKLE cell anemia; SICKLE cell anemia treatment; ASPIRIN; PATIENTS
- Publication
Middle East Journal of Internal Medicine, 2016, Vol 9, Issue 1, p3
- ISSN
1837-9052
- Publication type
Article
- DOI
10.5742/meim.2015.92773