We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT DELPHINIUM DENUDATUM ROOT, AGAINST ALCOHOL INDUCED HEPATOTOXIC RATS.
- Authors
Hussain, Mohd. Ashwaq; Suresh, D. K.; Gupta, V. Rama Mohan; Gouda, Shivraj; Veeresh; Srivani, V.
- Abstract
Delphinium denudatum Wall. (Ranunculaceae) is an indigenous medicinal herb popularly known as 'Jadwar' by the traditional healers in the sub-continent of Unani medicine. The objective of the present study was to evaluate the hepatoprotective effect of Ethanolic extract of Delphinium denudatum root in hepatotoxic rats. LD50 studies for Delphinium denudatum (Dd) root was conducted up to a dose level of 2000 mg/kg as per OECD guidelines Number 425. Animals were administered orally with alcohol (3.75 g/kg for 10 days) at 1 hour after the dose of Delphinium denudatum everyday for 10 consecutive days except rats in normal group. The protective effect was evaluated by using biochemical parameters including Aspartate Transaminase (AST), Alanine Transferase (ALT), Alkaline Phosphatase (ALP), Direct Bilirubin, Total Bilirubin and Cholesterol. The levels of these enzymes were found to be reduced in the cells following alcohol intoxication. Treatment with Delphinium denudatum root lead to significant amelioration of alcohol-induced changes including AST, ALT, ALP, Direct Bilirubin, Total Bilirubin and Cholesterol. The 400 mg/kg Dd dose gave the best result similar to Silymarin. Delphinium denudatum treatment (Per orally for 10 days) restored the alteredparameters in a dose-dependentmanner (36-100%).
- Subjects
DELPHINIUM; ALCOHOL; LABORATORY rats; ETHANOL; PLANT roots
- Publication
Advances in Pharmacology & Toxicology, 2012, Vol 13, Issue 1, p75
- ISSN
0973-2381
- Publication type
Article