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- Title
A DETAIL OF THE MOLECULAR ANATOMY OF THE MUSCULAR CELLS AND ITS CLINICAL IMPLICATION.
- Authors
Dragoş, D.; Ghenu, Maria Iuliana; Balcangiu-Stroescu, Andra-Elena; Tănăsescu, Maria Daniela; Adela Văcăroiu, Ileana; Tulin, A.; Ştiru, O.; Mihai, Andrada; Manea, Maria Mirabela; Ionescu, D.
- Abstract
The molecular anatomy of muscles cells includes, besides the ubiquitous Na+/K+ ATP-ase, the specific muscle channel Kir2.6, which intervenes as a counter-regulatory mechanism for preventing hypokalemia when Na+/K+ ATP-ase activity is increased, for whatever reason. Hyperthyroidism is such a condition in which the quantitative and qualitative enhancement of Na+/K+ ATP-ase may result in hypokalemia in the rare patient in which Na+/K+ ATP-ase driven potassium entry into the cells is not compensated by an appropriately increased Kir2.6 activity, resulting in potassium depletion of the extracellular space. Severe hypokalemia poses a vital risk by its potential cardiac complications - its correction may be difficult or even impossible as long as the cause, in rare cases hyperthyroidism, is not discovered and dealt with. This paper presents two cases in which unexplainable hypokalemia refractory to substitution treatment raised the suspicion of hyperthyroidism. Antithyroid treatment given after the diagnosis of hyperthyroidism had been confirmed corrected hypokalemia. Conclusions: when confronted with unexplainable hypokalemia, the clinician should consider hyperthyroidism as a possible diagnosis.
- Subjects
CELL anatomy; MEDICAL personnel; EXTRACELLULAR space; HYPOKALEMIA; DIAGNOSIS
- Publication
Romanian Journal of Functional & Clinical, Macro & Microscopical Anatomy & of Anthropology / Revista Româna de Anatomie Functionala si Clinica, Macro si Microscopica si de Antropologie, 2021, Vol 20, Issue 2, p111
- ISSN
1583-4026
- Publication type
Article