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- Title
Increased QT interval dispersion predicts 15-year cardiovascular mortality in type 2 diabetic subjects: the population-based Casale Monferrato Study.
- Authors
Giunti S; Gruden G; Fornengo P; Barutta F; Amione C; Ghezzo G; Cavallo-Perin P; Bruno G; Giunti, Sara; Gruden, Gabriella; Fornengo, Paolo; Barutta, Federica; Amione, Cristina; Ghezzo, Giuseppe; Cavallo-Perin, Paolo; Bruno, Graziella
- Abstract
<bold>Objective: </bold>To evaluate the predictive role of increased corrected QT (QTc) and QT interval dispersion (QTd) on all-cause and cardiovascular mortality in a large, unselected type 2 diabetic population.<bold>Research Design and Methods: </bold>The prospective study included 1,357 type 2 diabetic patients from the Casale Monferrato Study. At baseline, QTc intervals >0.44 s and QTd intervals >0.08 s were considered abnormally prolonged. Both all-cause and cardiovascular mortality were assessed 15 years after the baseline examination.<bold>Results: </bold>During the follow-up period, 862 subjects per 12,450 person-years died. Multivariate analysis showed that the hazard ratio (HR) of cardiovascular mortality was significantly increased in subjects with prolonged QTd (1.26 [95% CI 1.02-1.55]) and was only slightly reduced after multiple adjustments. Conversely, prolonged QTc did not increase the HRs for all-cause or cardiovascular mortality.<bold>Conclusions: </bold>Increased QTd predicts cardiovascular mortality after a long-term follow-up period in a large, unselected population of type 2 diabetic subjects.
- Publication
Diabetes Care, 2012, Vol 35, Issue 3, p581
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-1397