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- Title
Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial.
- Authors
Lawrence, Blake J.; Gasson, Natalie; Johnson, Andrew R.; Booth, Leon; Loftus, Andrea M.
- Abstract
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: <ext-link>12614001039673</ext-link>). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects.
- Subjects
PARKINSON'S disease treatment; COGNITION disorders treatment; ATTENTION; COGNITIVE therapy; LANGUAGE &; languages; HEALTH outcome assessment; QUALITY of life; SHORT-term memory; ACTIVITIES of daily living; RANDOMIZED controlled trials; TREATMENT effectiveness; EXECUTIVE function; TRANSCRANIAL direct current stimulation
- Publication
Parkinson's Disease (20420080), 2018, p1
- ISSN
2090-8083
- Publication type
Article
- DOI
10.1155/2018/4318475