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- Title
Prognostic significance of neutrophil-tolymphocyte ratio in collecting duct carcinoma.
- Authors
Satoru Taguchi; Hiroshi Fukuhara; Jimpei Miyakawa; Teppei Morikawa; Akihiro Naito; Taketo Kawai; Tetsuya Fujimura; Haruki Kume
- Abstract
Collecting (Bellini) duct carcinoma of the kidney is a rare lethal tumor, and its prognostic factors remain unclear. The present study investigated the prognostic significance of neutrophil-tolymphocyte ratio, which has recently been recognized as a readily available prognostic marker in various malignancies, in patients with collecting duct carcinoma. Of 11 patients who were pathologically diagnosed with collecting duct carcinoma at our institution, nine died of collecting duct carcinoma, one died of a postoperative complication, and one was alive, with a median follow-up period of 6 (range: 0-97) months. Both univariate and multivariate analyses associated neutrophilto- lymphocyte ratio ≥4 (median) with worse cancer-specific survival. Notably, the sole surviving patient maintained a low neutrophil-to-lymphocyte ratio (<4) both at the initial diagnosis and at the time of distant recurrence. These results suggest that neutrophil-to-lymphocyte ratio might serve as a useful biomarker for collecting duct carcinoma as well as other malignancies.
- Publication
Japanese Journal of Clinical Oncology, 2018, Vol 48, Issue 7, p692
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyy076