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- Title
Cushing's Syndrome in Adenocarcinoma of Lung Responding to Osilodrostat.
- Authors
Heleno, Caio Teixeira; Hong, Seung Pyo D.; Cho, Hyung-Gyo; Kim, Min Jeong; Park, Yeonggyeong; Chae, Young Kwang
- Abstract
Cushing's syndrome (CS), secondary to paraneoplastic syndrome, is more commonly seen in small cell lung cancer but never before reported in epidermal growth factor receptor-mutated adenocarcinoma of the lung. Here, we present a case of a patient whose symptoms of hypokalemia, hypertension, and progressive abnormal glucose levels led to further workup that revealed adrenocorticotropic hormone-dependent hypercortisolism. Her cortisol levels dropped after 1 month of osilodrostat treatment, while lung cancer was treated with osimertinib. The use of osilodrostat in paraneoplastic CS has been previously reported in only 3 patients.
- Subjects
CUSHING'S syndrome; SMALL cell lung cancer; PARANEOPLASTIC syndromes; EPIDERMAL growth factor; LUNGS; EPIDERMAL growth factor receptors
- Publication
Case Reports in Oncology, 2023, Vol 16, Issue 1, p130
- ISSN
1662-6575
- Publication type
Article
- DOI
10.1159/000527824