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- Title
SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses.
- Authors
Arora, Ankit; Kolberg, Jan Eric; Srinivasachar Badarinarayan, Smitha; Savytska, Natalia; Munot, Daksha; Müller, Martin; Krchlíková, Veronika; Sauter, Daniel; Bansal, Vikas
- Abstract
Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. By analyzing ChIP-sequencing data sets, we show that SARS-CoV-2 infection induces H3K27 acetylation of several loci within the LTR69 subfamily of ERVs. Using functional assays, we identified one SARS-CoV-2-activated LTR69 locus, termed Dup69, which exhibits regulatory activity and is responsive to the transcription factors IRF3 and p65/RELA. LTR69_Dup69 is located about 500 bp upstream of a long non-coding RNA gene (ENSG00000289418) and within the PTPRN2 gene encoding a diabetes-associated autoantigen. Both ENSG00000289418 and PTPRN2 showed a significant increase in expression upon SARS-CoV-2 infection. Thus, our study sheds light on the interplay of exogenous with endogenous viruses and helps to understand how ERVs regulate gene expression during infection.
- Subjects
ENDOGENOUS retroviruses; SARS-CoV-2; RETROVIRUSES; LINCRNA; EPIGENETICS; GENE expression
- Publication
Mobile DNA, 2023, Vol 14, Issue 1, p1
- ISSN
1759-8753
- Publication type
Article
- DOI
10.1186/s13100-023-00299-1