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- Title
Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4 and the Risk of Late-Onset Alzheimer Disease in African Americans.
- Authors
Reitz, Christiane; Jun, Gyungah; Naj, Adam; Rajbhandary, Ruchita; Vardarajan, Badri Narayan; Li-San Wang; Valladares, Otto; Chiao-Feng Lin; Larson, Eric B.; Graff-Radford, Neill R.; Evans, Denis; De Jager, Philip L.; Crane, Paul K.; Buxbaum, Joseph D.; Murrell, Jill R.; Raj, Towfique; Ertekin-Taner, Nilufer; Logue, Mark; Baldwin, Clinton T.; Green, Robert C.
- Abstract
The article discusses research which examined genetic loci associated with late-onset Alzheimer disease in African Americans. Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for people of European ancestry. Case-control and family-based data sets were used in assessing the association of Alzheimer disease with genotyped and imputed single-nucleotide polymorphisms (SNPs). Findings revealed that genome-wide significance in fully adjusted models was observed for a SNP in ABCA7 genes. In addition, loci previously linked with Alzheimer disease were replicated in gene-based analyses accounting for linkage disequilibrium between markers.
- Subjects
LOCUS (Genetics); GENETICS of Alzheimer's disease; DISEASES in African Americans; SINGLE nucleotide polymorphisms; LINKAGE disequilibrium; POPULATION genetics
- Publication
JAMA: Journal of the American Medical Association, 2013, Vol 309, Issue 14, p1483
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2013.2973