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- Title
Incidence of Breast Cancer and Its Subtypes in Relation to Individual and Multiple Low-Penetrance Genetic Susceptibility Loci.
- Authors
Reeves, Gillian K.; Travis, Ruth C.; Green, Jane; Bull, Diana; Tipper, Sarah; Baker, Krys; Beral, Valerie; Peto, Richard; Bell, John; Zelenika, Diana; Lathrop, Mark
- Abstract
The article discusses medical research on the risks of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci in Great Britain. It investigates 14 individual single-nucleotide polymorphisms (SNPs) previously linked to breast cancer. It mentions that participants in the study include 10,306 women with breast cancer and 10,393 women without breast cancer who provided blood samples for genotyping in a large prospective study in the country in 2005 to 2008. It concludes that breast cancer was substantially more predictive of estrogen receptor (ER)-positive than of ER-negative.
- Subjects
UNITED Kingdom; BREAST cancer research; CANCER susceptibility; GENETIC polymorphisms; GENOTYPE-environment interaction; ESTROGEN receptors; DISEASE susceptibility; CANCER in women; MEDICAL research
- Publication
JAMA: Journal of the American Medical Association, 2010, Vol 304, Issue 4, p426
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2010.1042