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- Title
Protein-induced satiation and the calcium-sensing receptor.
- Authors
Ojha, Utkarsh
- Abstract
Obesity is a major global health issue. High-protein diets have been shown to be associated with weight loss and satiety. The precise mechanism by which protein-rich diets promote weight loss remains unclear. Evidence suggests amino acids, formed as a consequence of protein digestion, are sensed by specific receptors on L-cells in the gastrointestinal (GI) tract. These L-cells respond by secreting gut hormones that subsequently induce satiety. In recent years, the calcium-sensing receptor has been identified in several cells of the GI tract, including L-cells, and suggested to sense specific amino acids. This review evaluates the evidence for protein-rich diets in inducing weight loss and how the calcium-sensing receptor may be implicated in this phenomenon. Commandeering the mechanisms by which elements of a protein-rich diet suppress appetite may provide another successful avenue for developing anti-obesity drugs.
- Subjects
HIGH-protein diet; CALCIUM-sensing receptors; WEIGHT loss; STIMULUS satiation; AMINO acid analysis; PHYSIOLOGY
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2018, Vol 11, p45
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/DMSO.S156597