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- Title
Neutrophilic spongiosis in pemphigus herpetiformis.
- Authors
Huhn, Karen M.; Tron, Victor A.; Nguyen, Nhiem; Trotter, Martin J.
- Abstract
Pemphigus herpetiformis is a rare pemphigus variant with light microscopic features that have historically been described as either "acantholytic dermatitis herpertiformis" or as "eosinophilic spongiosis in pemphigus". The clinical features of this form of permphigus are reminiscent of dermatitis herpertiformis; however, the direct immunofluorescence finding of epidermal intercellular IgG deposition is that of the pemphigus group. We report two patients with clinical presentations suggestive of dermatitis herpetiformis in whom the histopathologic features were those of a neutrophilic intraepidermal blistering disorder. Biopsies showed marked epidermal spongiosis with midepidermal acantholytic vesicles containing predominantly was positive for epidermal intercellular IgG; IgA deposition was not present. Neutrophilic spongiosis, in the absence of a prominent eosinophilic infiltrate, should be recognized as an early finding in some cases of pemphigus, and immunofluorescence studies are justified when this histologic feature is encountered in a skin biopsy.
- Subjects
PEMPHIGUS; DERMATITIS herpetiformis; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN G; HISTOPATHOLOGY; SKIN biopsy
- Publication
Journal of Cutaneous Pathology, 1996, Vol 23, Issue 3, p264
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1996.tb01477.x