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- Title
Pulmonary hypertension in Nigerian adults with sickle cell anemia.
- Authors
Amadi, Valentine N.; Balogun, Michael O.; Akinola, Norah O.; Adebayo, Rasaaq A.; Akintomide, Anthony O.
- Abstract
<bold>Background: </bold>Sickle cell anemia (SCA) is the commonest hemoglobinopathy and is associated with high morbidity and mortality. Pulmonary hypertension (PH) is reported to play a significant role in this regard. There is very limited literature on PH in SCA in Nigeria.<bold>Objectives: </bold>The objectives of this study were to determine the prevalence of Doppler-derived PH in SCA, assess its influence on exercise capacity, and determine the correlates and predictors of measures of estimated pulmonary pressure.<bold>Methods: </bold>A total of 92 SCA subjects had echocardiography and 6-minute self-paced walking exercise. PH was diagnosed by Doppler echocardiography on finding a tricuspid regurgitant velocity (TRV) of ≥2.5 m/s. The pulmonary flow profile was also assessed to estimate mean pulmonary arterial pressure (MPAP).<bold>Results: </bold>Doppler-derived PH was detected in 23.9% of adults with SCA. The 6-minute walking distance (6MWD) was significantly lower in SCA adults with PH than in those without PH (380.33 ± 63.17 m vs 474.28 ± 76.74 m; p = 0.014). TRV and estimated MPAP had a significant inverse correlation with the 6MWD (r = -0.442; p < 0.001 and r = -0.571; p < 0.001, respectively).<bold>Conclusion: </bold>PH as derived by Doppler is common in Nigerian adults with SCA and has a significantly negative influence on exercise capacity. Screening for PH should be encouraged to optimize management and thus improve their quality of life and life expectancy.
- Subjects
NIGERIA; PULMONARY hypertension diagnosis; SICKLE cell anemia diagnosis; DISEASE prevalence; ECHOCARDIOGRAPHY; QUALITY of life; NIGERIANS; DISEASES; ACADEMIC medical centers; ARTERIES; BLOOD pressure; DOPPLER echocardiography; HEART valve diseases; PULMONARY artery; PULMONARY hypertension; SICKLE cell anemia; TRICUSPID valve; EXERCISE tolerance
- Publication
Vascular Health & Risk Management, 2017, Vol 13, p153
- ISSN
1176-6344
- Publication type
journal article
- DOI
10.2147/VHRM.S92799