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- Title
Multiple osteolytic lesions of the jaws in a patient with neurofibromatosis type I. A case report and focused literature review.
- Authors
Tosios, K.I.; Delli, K.; Makris, N.
- Abstract
We describe the case of a patient diagnosed with neurofibromatosis type 1 (NF1) where unusually extensive and multiple osteolytic lesions of both jaws consistent with central giant cell granulomas (CGCG) caused massive bone destruction and left her almost "jawless." The patient was a 58‐year‐old woman who at the age of 15 years was diagnosed with NF1 and at the age of 53 years underwent radiation therapy for nasal obstruction due to CGCG. The most significant intraoral findings were brown tumors on the maxillary gingiva; bilateral expansion of the hard palate; and a yellow mass on the floor of the mouth. Head and neck examination revealed mandibular asymmetry and features consistent with NF1. Panoramic radiograph and cone beam computed tomography disclosed multiple radiolucent masses. Although the occurrence of multiple CGCG of the jaws in patients with NF1 is rare, early diagnosis, regular follow‐up and proper therapeutic intervention may limit the extent of bone destruction.
- Subjects
CONE beam computed tomography; NEUROFIBROMATOSIS 1; JAWS; LITERATURE reviews; HARD palate
- Publication
Oral Surgery (1752-2471), 2019, Vol 12, Issue 2, p126
- ISSN
1752-2471
- Publication type
Article
- DOI
10.1111/ors.12389