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- Title
Self-Reported Cancer-Related Cognitive Impairment in Patients With Breast Cancer Is Associated With Potassium Channel Gene Polymorphisms.
- Authors
Oppegaard, Kate R.; Hammer, Marilyn J.; Conley, Yvette P.; Harris, Carolyn S.; Cooper, Bruce A.; Paul, Steven M.; Joosun Shin; Morse, Lisa; Abrams, Gary M.; Levine, Jon D.; Miaskowski, Christine
- Abstract
OBJECTIVES: To evaluate for associations of polymorphisms for potassium channel genes in patients with breast cancer who were classified as having high or low-moderate levels of cancer-related cognitive impairment (CRCI). SAMPLE & SETTING: 397 women who were scheduled to undergo surgery for breast cancer on one breast were recruited from breast care centers located in a comprehensive cancer center, two public hospitals, and four community practices. METHODS & VARIABLES: CRCI was assessed using the Attentional Function Index prior to and for six months after surgery. The attentional function classes were identified using growth mixture modeling. RESULTS: Differences between patients in the high versus low-moderate attentional function classes were evaluated. Six single nucleotide polymorphisms for potassium channel genes were associated with low-moderate class membership. IMPLICATIONS FOR NURSING: The results contribute to knowledge of the mechanisms for CRCI. These findings may lead to the identification of high-risk patients and the development of novel therapeutics.
- Subjects
COGNITION disorder risk factors; DNA analysis; SELF-evaluation; RISK assessment; RESEARCH funding; BREAST tumors; POTASSIUM; QUESTIONNAIRES; FISHER exact test; MULTIPLE regression analysis; CANCER patients; DESCRIPTIVE statistics; CHI-squared test; MANN Whitney U Test; GENETIC polymorphisms; GENE expression; NUCLEOTIDES; ODDS ratio; COGNITION disorders; CONCEPTUAL structures; DATA analysis software; CONFIDENCE intervals; ALLELES; GENOTYPES; GENETICS; DISEASE complications
- Publication
Oncology Nursing Forum, 2024, Vol 51, Issue 3, p263
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/24.ONF.263-274