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- Title
SÍNDROME PULMONAR POR HANTAVIRUS ASOCIADO AL ORTHOHANTAVIRUS ALTO PARAGUAY EN ARGENTINA. ESTUDIO DEL CASO HUMANO Y POTENCIAL ROEDOR RESERVORIO.
- Authors
Martin, M. Laura; Brignone, Julia M.; Sen, Carina N.; García, Jorge B.; Cúdos, M. Carolina; Andreu, Verónica; Calatayud, Silvia; GonzálezIttig, Raúl E.
- Abstract
Hantavirus pulmonary syndrome (HPS) is an acute viral illness caused by members of the genus Orthohantavirus, family Hantaviridae. In Argentina, there is evidence of the circulation of several pathogenic genotypes in different rodent reservoirs. In addition, at least four non-pathogenic genotypes for humans have been identified. In 2020, a patient inhabiting Colonia Montefiore (province of Santa Fe) without any travel history was diagnosed with HPS. The orthohantavirus genotype detected in the patient was Alto Paraguay. This genotype had previously been detected only in Paraguay in rodents identified as Holochilus chacarius, but not in patients with HPS. Since the circulation of this genotype was unknown in Argentina, we studied the rodent communities in rural areas near the site of the human infection case. Fifty-nine rodents were captured, and one specimen of H. chacarius proved to be infected with the Alto Paraguay genotype. The viral sequences of the rodent were compared with those of the patient, finding 100 % nucleotide identity for the fragments of the S and M genomic segments. These results confirm the circulation of a new pathogenic genotype of orthohantavirus in Argentina, and provide evidence of its potential association with rodents of the species H. chacarius, important information for prevention measures.
- Subjects
ARGENTINA; PARAGUAY; SANTA Fe (Argentina : Province); ACUTE diseases; GENOTYPES; RURAL geography; RODENTS; INFORMATION measurement; MOSAIC viruses
- Publication
Journal of Neotropical Mammalogy / Mastozoologia Neotropical, 2024, Vol 31, Issue 1, p1
- ISSN
0327-9383
- Publication type
Article
- DOI
10.31687/saremMN.24.31.01.07.e0983