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- Title
Characteristic and Import Mechanism of Protein Nuclear Translocation.
- Authors
Zi Yan SUN; Zhi Peng FAN
- Abstract
Coordination and information exchange among the various organelles ensure the precise and orderly functioning of eukaryotic cells. Interaction between the cytoplasm and nucleoplasm is crucial for many physiological processes. Macromolecular protein transport into the nucleus requires assistance from the nuclear transport system. These proteins typically contain a nuclear localisation sequence that guides them to enter the nucleus. Understanding the mechanism of nuclear import of macromolecular proteins is important for comprehending cellular processes. Investigation of disease-related alterations can facilitate the development of novel therapeutic strategies and provide additional evidence for clinical trials. This review provides an overview of the proteins involved in nuclear transport and the mechanisms underlying macromolecular protein transport.
- Subjects
NUCLEAR transport; NUCLEAR proteins; NUCLEAR pore complex; PROTEIN transport; NUCLEOCYTOPLASMIC interactions
- Publication
Chinese Journal of Dental Research, 2024, Vol 27, Issue 1, p39
- ISSN
1462-6446
- Publication type
Article
- DOI
10.3290/j.cjdr.b5136729