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- Title
Definitions of recovery and outcomes of major depression: results from a 10-year follow-up.
- Authors
Furukawa, T. A.; Fujita, A.; Harai, H.; Yoshimura, R.; Kitamura, T.; Takahashi, K.
- Abstract
Objective: Consensus operational definitions for symptomatic remission and recovery of a major depressive episode have been proposed but only irregularly followed. Method: We examined the predictive validity of different definitions of recovery in a multi-center 10-year follow-up study of an inception cohort of untreated unipolar major depressive episodes ( n = 95). Time to recovery and time to recurrence after recovery were estimated by Kaplan–Meier survival analyses for alternative definitions requiring 2, 4, 6 or 12 months of remission to declare recovery. Results: The median time to recovery was 3.0, 4.0, 4.0 and 12.0 months respectively. The index episode lasted longer than 24 months in 9.4%, 9.2%, 12.6% and 24.5%. The median time to subthreshold recurrence was 16.0, 32.0, 42.0 and 74.0 months. Conclusion: Either 4- or 6-month duration of remission defined a change point before which the episode was continuous and after which the recurrence was reasonably unlikely.
- Subjects
MENTAL depression; DEFINITIONS; PATIENTS; COHORT analysis; SURVIVAL analysis (Biometry)
- Publication
Acta Psychiatrica Scandinavica, 2008, Vol 117, Issue 1, p35
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/j.1600-0447.2007.01119.x