We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesions
- Authors
Sun, C.A.; Liu, J.F.; Wu, D.M.; Nieh, S.; Yu, C.P.; Chu, T.Y.
- Abstract
Objectives: This case-control study was conducted to investigate the role of viral load of high-risk human papillomaviruses (HPVs) in the development of cervical squamous intraepithelial lesions (SILs) and invasive cancers. Methods: A total of 30 female cases who had histological evidence of low-grade SIL (n=10) or high-grade SIL and above (n=20) were identified as the case group at the Tri-Service General Hospital, Taipei between September 1998 and March 1999. In addition, 80 female controls who had normal cervical cytology were enrolled and individually matched on age (±5 years) and date of recruitment to each case. Cervical swabs collected from study subjects were tested for the positivity and viral load of high-risk HPVs by Hybrid Capture II assay. Additionally, subjects completed a risk factor questionnaire. Results: Among sex behavioral factors studied, younger age at first intercourse was associated with a significantly elevated risk of cervical SIL and invasive cancers. With respect to HPV infection, high-risk HPV DNA was present in 70% (21/30) of case and 21% (17/80) of control subjects, resulting in an odds ratio (OR) of 6.6 [95% confidence interval (C.I.)=2.6–17.0]. Moreover, women who had a high viral load were at significantly greater risk for cervical SIL and invasive cancers than those who were infected with a low viral load (OR=18.0, 95% C.I.=3.0–108.5). Conclusions: Among the variables tested, infection with a high viral load of high-risk HPVs is the strongest determinant for cervical SIL and cervical cancers in Taiwan.
- Subjects
PAPILLOMAVIRUSES; PRECANCEROUS conditions; SQUAMOUS cell carcinoma; COMPARATIVE studies; EPITHELIAL cell tumors; RESEARCH methodology; MEDICAL cooperation; PAPILLOMAVIRUS diseases; RESEARCH; RISK assessment; HUMAN sexuality; TUMORS; CERVIX uteri tumors; VIRAL load; EVALUATION research; CASE-control method; CERVICAL intraepithelial neoplasia; DISEASE complications; PHYSIOLOGY
- Publication
International Journal of Gynecology & Obstetrics, 2002, Vol 76, Issue 1, p41
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/S0020-7292(01)00529-X