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- Title
SDS-PAGE analysis of urinary proteins in dogs with heartworm disease.
- Authors
Beristain-Ruiz, D. M.; Carretón, E.; Rodríguez-Alarcón, C. A.; Montoya-Alonso, J. A.; Barrera, R.
- Abstract
The aim of the study was to describe the urinary electrophoretic pattern of dogs with heartworm disease. Urine samples from 15 heartworm-infected and 15 healthy dogs were taken. Urinary specific gravity, urinary protein concentration and the urine protein/creatinine (U P/C) ratio were determined. Urine proteins were fractionated using SDS-PAGE. Results showed statistically significant differences for the U P/C ratio (P<0.05) but not for USG and urinary protein concentrations (P>0.05) between groups. Urinary protein SDSPAGE analysis showed eight distinct bands in the urine of heartworm-infected dogs. The presence of proteins exclusively found in the urine of infected dogs suggests renal damage, even in cases of light proteinuria, indicating that SDS-PAGE is a sensitive method for the identification and characterisation of renal proteinuria in dogs with heartworm disease.
- Subjects
CANINE heartworm disease diagnosis; CANINE heartworm disease treatment; DIROFILARIA immitis; PROTEINURIA; ANIMAL diseases; PREVENTION; THERAPEUTICS
- Publication
Iranian Journal of Veterinary Research, 2013, Vol 14, Issue 3, p245
- ISSN
1728-1997
- Publication type
Article