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- Title
Two-year neurodevelopmental outcome in extremely preterm-born children: The Austrian Preterm Outcome Study Group.
- Authors
Kiechl-Kohlendorfer, Ursula; Simma, Burkhard; Berger, Angelika; Urlesberger, Berndt; Wald, Martin; Haiden, Nadja; Fuiko, Renate; Ndayisaba, Jean-Pierre
- Abstract
Aim: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. Methods: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function. Results: 2378 out of 2905 (81.9%) live-born infants survived to 2 years of corrected age. Follow-up data were available for 1488 children (62.6%). Overall, 43.0% had no, 35.0% mild and 22.0% moderate-to-severe impairment. The percentage of children with moderate-to-severe neurodevelopmental impairment decreased with increasing gestational age and was 31.4%, 30.5%, 23.3%, 19.0% and 16.5% at 23, 24, 25, 26 and 27 weeks gestational age (p < 0.001). Results did not change over the 10-year period. In multivariate analysis, neonatal complications as well as male sex were significantly associated with an increased risk of neurodevelopmental impairment. Conclusion: In this cohort study, a 22.0% rate of moderate-to-severe neurodevelopmental impairment was observed among children born extremely preterm. This national data is important for both counselling parents and guiding the allocation of health resources.
- Subjects
AUSTRIA; NEURAL development; PREMATURE infants; NEUROLOGIC examination; GESTATIONAL age; INFANT development
- Publication
Acta Paediatrica, 2024, Vol 113, Issue 6, p1278
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/apa.17187