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- Title
Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.
- Authors
Baker, Edward N.; Squire, Christopher J.; Young, Paul G.
- Abstract
The ability of bacteria to adhere to other cells or to surfaces depends on long, thin adhesive structures that are anchored to their cell walls. These structures include extended protein oligomers known as pili and single, multi-domain polypeptides, mostly based on multiple tandem Ig-like domains. Recent structural studies have revealed the widespread presence of covalent cross-links, not previously seen within proteins, which stabilize these domains. The cross-links discovered so far are either isopeptide bonds that link lysine side chains to the side chains of asparagine or aspartic acid residues or ester bonds between threonine and glutamine side chains. These bonds appear to be formed by spontaneous intramolecular reactions as the proteins fold and are strategically placed so as to impart considerable mechanical strength.
- Subjects
BACTERIAL adhesins; GRAM-positive bacteria; ISOPEPTIDE bonds; LYSINE; ASPARTIC acid; POLYPEPTIDES
- Publication
Biochemical Society Transactions, 2015, Vol 43, Issue 5, p787
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20150066