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- Title
Oxidation of nuclear thioredoxin during oxidative stress
- Authors
Watson, Walter H.; Jones, Dean P.
- Abstract
Thioredoxin 1 (Trx1) is a key redox control system within the nucleus, yet little is known about the sensitivity of nuclear Trx1 to oxidative stress. The present study compared oxidant-induced changes in the redox states of nuclear Trx1, cytoplasmic Trx1, and cellular glutathione (GSH). Nuclear Trx1 was more reducing than cytoplasmic Trx1 and cellular GSH in proliferating cells. tert-Butylhydroperoxide caused an increase in the total amount of nuclear Trx1, but this was accompanied by a 60 mV oxidation. Thus, the increase in nuclear Trx1 levels did not correspond to an increase in the overall reducing capacity of Trx1 in the nucleus.
- Subjects
THIOREDOXIN; NUCLEASES
- Publication
FEBS Letters, 2003, Vol 543, Issue 1-3, p144
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00430-7