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- Title
Crosslinking of CD44 on human osteoblastic cells upregulates ICAM-1 and VCAM-1
- Authors
Fujii, Yuko; Fujii, Koichi; Nakano, Kazuhisa; Tanaka, Yoshiya
- Abstract
Cell adhesion of osteoblasts and osteoclastic precursors of hematopoietic origin is a prerequisite for osteoclast maturation. We have investigated the relevance of osteoblast–matrix binding and regulation of adhesion molecules to this process. Human osteoblastic cells highly expressed CD44, a major receptor for hyaluronan present in the surrounding bone matrix. Crosslinking of CD44 on osteoblastic cells with specific antibodies augmented the expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1. Hyaluronan, the major ligand of CD44, also up-regulated ICAM-1 expression. Stimulation of CD44 on osteoblastic cells amplified their adhesion to monocytic cells through ICAM-1 and VCAM-1. These results suggest that such crosstalk among distinct adhesion molecules may be relevant to bone metabolism, including osteoclastogenesis.
- Subjects
OSTEOCLASTS; CELL adhesion molecules
- Publication
FEBS Letters, 2003, Vol 539, Issue 1-3, p45
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00182-0