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- Title
Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device.
- Authors
Hussain, Iqram; Young, Seo; Kim, Chang Ho; Benjamin, Ho Chee Meng; Park, Se Jin; ÓLaighin, Gearóid
- Abstract
Physiological signals are immediate and sensitive to neural and cardiovascular change resulting from brain stimulation, and are considered as a quantifying tool with which to evaluate the association between brain stimulation and cognitive performance. Brain stimulation outside a highly equipped, clinical setting requires the use of a low-cost, ambulatory miniature system. The purpose of this double-blind, randomized, sham-controlled study is to quantify the physiological biomarkers of the neural and cardiovascular systems induced by a microwave brain stimulation (MBS) device. We investigated the effect of an active MBS and a sham device on the cardiovascular and neurological responses of ten volunteers (mean age 26.33 years, 70% male). Electroencephalography (EEG) and electrocardiography (ECG) were recorded in the initial resting-state, intermediate state, and the final state at half-hour intervals using a portable sensing device. During the experiment, the participants were engaged in a cognitive workload. In the active MBS group, the power of high-alpha, high-beta, and low-beta bands in the EEG increased, and the power of low-alpha and theta waves decreased, relative to the sham group. RR Interval and QRS interval showed a significant association with MBS stimulation. Heart rate variability features showed no significant difference between the two groups. A wearable MBS modality may be feasible for use in biomedical research; the MBS can modulate the neurological and cardiovascular responses to cognitive workload.
- Subjects
BRAIN stimulation; HEART beat; THETA rhythm; CARDIOVASCULAR fitness; TRANSCRANIAL direct current stimulation; BIOMARKERS; MICROWAVES
- Publication
Sensors (14248220), 2021, Vol 21, Issue 5, p1896
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s21051896