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- Title
Tocilizumab treatment for new onset refractory status epilepticus.
- Authors
Jun, Jin‐Sun; Lee, Soon‐Tae; Kim, Ryul; Chu, Kon; Lee, Sang Kun; Jun, Jin-Sun; Lee, Soon-Tae
- Abstract
We investigated the therapeutic potential of the interleukin-6 receptor inhibitor tocilizumab in 7 patients with new onset refractory status epilepticus (NORSE) who remained refractory to conventional immunotherapy with rituximab (n = 5) or without rituximab (n = 2). Status epilepticus (SE) was terminated after 1 or 2 doses of tocilizumab in 6 patients with a median interval of 3 days from the initiation. They had no recurrence of SE during the observation. However, 2 patients experienced severe adverse events related to infection during the tocilizumab therapy. Further prospective controlled studies are warranted to validate the efficacy and safety of tocilizumab in patients with NORSE. Ann Neurol 2018;84:940-945.
- Subjects
TOCILIZUMAB; INTERLEUKIN-6 receptors; IMMUNOTHERAPY; STATUS epilepticus treatment; INFECTION treatment
- Publication
Annals of Neurology, 2018, Vol 84, Issue 6, p940
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.25374