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- Title
Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics.
- Authors
Lucey, Brendan P.; Hicks, Terry J.; McLeland, Jennifer S.; Toedebusch, Cristina D.; Boyd, Jill; Elbert, Donald L.; Patterson, Bruce W.; Baty, Jack; Morris, John C.; Ovod, Vitaliy; Mawuenyega, Kwasi G.; Bateman, Randall J.
- Abstract
Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with 13 C6 -leucine to measure amyloid β kinetics. We found that sleep deprivation increased overnight amyloid β38, amyloid β40, and amyloid β42 levels by 25 to 30% via increased overnight amyloid β production relative to sleeping controls. These findings suggest that disrupted sleep increases Alzheimer disease risk via increased amyloid β production. Ann Neurol 2018;83:197-204.
- Subjects
ALZHEIMER'S disease risk factors; CEREBROSPINAL fluid; GAMMA-hydroxybutyrate; AMYLOID beta-protein; LEUCINE
- Publication
Annals of Neurology, 2018, Vol 83, Issue 1, p197
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.25117