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- Title
Amylin Levels Decrease 1 Month After Roux--en-Y Gastric Bypass Surgery in Patients with Type 2 Diabetes.
- Authors
Laferrere, Blandine; Tran, Hao C.; Egger, Joseph; Yap, Kimberly P.; Teixeira, Julio; McGinty, James; Olivan, Blanca
- Abstract
Amylin is a peptide co-secreted with insulin in response to several stimuli, including hyperglycemia. The secretion of amylin is impaired in obese subjects with Type 2 Diabetes (T2DM), and varies with the degree of islet dysfunction. Hyperamylinemia has been described in the early stage of T2DM and in the presence of chronic hyperglycemia. The goal of this study was to investigate the changes in amylin levels 1 month after Roux-en-Y Gastric Bypass Surgery (RY-GBP). Seven obese women (Patients), age 43.0±9.5 y, BMI 43.6±7.4 kg/m², fasting glucose 147.1 ± 34.7 mg/dl, fasting insulin 22.6+10.5 µU/mL, HbA 1C 6.8±0.7%, with T2DM of less than 2 years duration, and 8 lean non-diabetic controls (Controls) (5F, 3M, BMI= 23.1±2.5 kg/m²) were studied. Serum amylin and insulin levels were measured during an oral glucose tolerance test (50gr, OGTT) before and 1 month after RY-GBP. Analyses were performed using SPSS 13.0. Results are reported as mean ± SD. Patients' diabetes medications were discontinued 3 days prior to the baseline OGTT before the surgery. None of the patients were taking insulin, thiazolinedione or beta-blocker before RY-GBP or any diabetes medication after RY-GBP. One month after RY-GBP, body weight decreased by 9.7±3.1 kg (p<0.001) and glycemic levels improved. Fasting amylin levels and total amylin AUC[0-180min] decreased (p=0.021, p=0.045,) and fasting and peak insulin:amylin increased (p=0.047, p=0.017) after RY-GBP. Amylin levels increased during the OGTT, with a different pattern witnessed in Controls versus Patients before RY-GBP (p=0.01), and in Patients before and after RY-GBP (p<0.001). Fasting insulin:amylin (p= 0.029) and peak insulin:amylin (p=0.0324) were higher after RY-GBP than in Controls. Early (30min) amylin and insulin responses were strongly correlated (r= 0.820, p<0.001) in Patients and Controls. These data suggest that as early as I month after RY-GBP, changes in amylin and insulin levels occur, in parallel with improvement in T2DM control. Acknowledgment: This work was funded by the NIH DK67561, RR00645, DK-26687, ADA CRA 7-05-CR-18 and by Amylin Pharmaceutical Inc. ADA-Funded Research
- Subjects
AMYLIN; GASTRIC bypass; OVERWEIGHT persons; TYPE 2 diabetes; INSULIN; BLOOD sugar
- Publication
Diabetes, 2007, Vol 56, pA674
- ISSN
0012-1797
- Publication type
Article