We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review.
- Authors
Uceda, Sara; Echeverry-Alzate, Víctor; Reiriz-Rojas, Manuel; Martínez-Miguel, Esther; Pérez-Curiel, Ana; Gómez-Senent, Silvia; Beltrán-Velasco, Ana Isabel
- Abstract
The comprehensive narrative review conducted in this study delves into the mechanisms of communication and action at the molecular level in the human organism. The review addresses the complex mechanism involved in the microbiota–gut–brain axis as well as the implications of alterations in the microbial composition of patients with neurodegenerative diseases. The pathophysiology of neurodegenerative diseases with neuronal loss or death is analyzed, as well as the mechanisms of action of the main metabolites involved in the bidirectional communication through the microbiota–gut–brain axis. In addition, interventions targeting gut microbiota restructuring through fecal microbiota transplantation and the use of psychobiotics—pre- and pro-biotics—are evaluated as an opportunity to reduce the symptomatology associated with neurodegeneration in these pathologies. This review provides valuable information and facilitates a better understanding of the neurobiological mechanisms to be addressed in the treatment of neurodegenerative diseases.
- Subjects
FECAL microbiota transplantation; NEURODEGENERATION; THERAPEUTICS; DYSBIOSIS; GUT microbiome
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 17, p13294
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241713294