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- Title
The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder.
- Authors
Chan, Sze Yan; Wan, Crystal Wing Tung; Law, Tin Yu Samuel; Chan, David Yiu Leung; Fok, Ellis Kin Lam
- Abstract
Apart from the paternal half of the genetic material, the male gamete carries assorted epigenetic marks for optimal fertilization and the developmental trajectory for the early embryo. Recent works showed dynamic changes in small noncoding RNA (sncRNA) in spermatozoa as they transit through the testicular environment to the epididymal segments. Studies demonstrated the changes to be mediated by epididymosomes during the transit through the adluminal duct in the epididymis, and the changes in sperm sncRNA content stemmed from environmental insults significantly altering the early embryo development and predisposing the offspring to metabolic disorders. Here, we review the current knowledge on the establishment of the sperm sncRNA transcriptome and their role in male-factor infertility, evidence of altered offspring health in response to the paternal life experiences through sperm sncRNA species and, finally, their implications in assisted reproductive technology in terms of epigenetic inheritance.
- Subjects
NON-coding RNA; SPERMATOZOA; REPRODUCTIVE technology; TRANSCRIPTOMES; MALE infertility; HEREDITY; INFERTILITY
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 24, p15716
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232415716