We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Multi-Dimensional Biomarker Landscape in Cancer Immunotherapy.
- Authors
Lee, Jing Yi; Kannan, Bavani; Lim, Boon Yee; Li, Zhimei; Lim, Abner Herbert; Loh, Jui Wan; Ko, Tun Kiat; Ng, Cedric Chuan-Young; Chan, Jason Yongsheng
- Abstract
The field of immuno-oncology is now at the forefront of cancer care and is rapidly evolving. The immune checkpoint blockade has been demonstrated to restore antitumor responses in several cancer types. However, durable responses can be observed only in a subset of patients, highlighting the importance of investigating the tumor microenvironment (TME) and cellular heterogeneity to define the phenotypes that contribute to resistance as opposed to those that confer susceptibility to immune surveillance and immunotherapy. In this review, we summarize how some of the most widely used conventional technologies and biomarkers may be useful for the purpose of predicting immunotherapy outcomes in patients, and discuss their shortcomings. We also provide an overview of how emerging single-cell spatial omics may be applied to further advance our understanding of the interactions within the TME, and how these technologies help to deliver important new insights into biomarker discovery to improve the prediction of patient response.
- Subjects
IMMUNE checkpoint proteins; CANCER treatment; IMMUNOTHERAPY; TUMOR microenvironment; TREATMENT effectiveness; BIOMARKERS
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 14, p7839
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23147839