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- Title
The Role of Calcium Signaling in Melanoma.
- Authors
Zhang, Haoran; Chen, Zhe; Zhang, Aijun; Gupte, Anisha A.; Hamilton, Dale J.
- Abstract
Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca2+]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca2+ pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. We documented calcium-dependent endoplasmic reticulum (ER) stress and mitochondria dysfunction, by targeting calcium channels and influencing [Ca2+]i and calcium homeostasis, and attenuated drug resistance in melanoma management.
- Subjects
CALCIUM; POTASSIUM channels; SODIUM channels; INTRACELLULAR calcium; MELANOMA; CALCIUM channels
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 3, p1010
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23031010