We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular Mechanism of Cannabinoids in Cancer Progression.
- Authors
Pagano, Cristina; Navarra, Giovanna; Coppola, Laura; Bifulco, Maurizio; Laezza, Chiara; Schlicker, Eberhard
- Abstract
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis.
- Subjects
CANNABINOIDS; CANCER invasiveness; PERIPHERAL nervous system; CANNABINOID receptors; CENTRAL nervous system; METASTASIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 7, p3680
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22073680