We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats.
- Authors
Sufiun, Abu; Rahman, Asadur; Rafiq, Kazi; Fujisawa, Yoshihide; Nakano, Daisuke; Kobara, Hideki; Masaki, Tsutomu; Nishiyama, Akira
- Abstract
The aim of the present study is to investigate whether a disruption of the dipping pattern of blood pressure (BP) is associated with the progression of renal injury in Dahl salt-sensitive (DSS) hypertensive rats. Seven-week-old DSS rats were fed a high salt diet (HSD; 8% NaCl) for 10 weeks, followed by a transition to a normal salt diet (NSD; 0.3% NaCl) for 4 weeks. At baseline, NSD-fed DSS rats showed a dipper-type circadian rhythm of BP. By contrast, HSD for 5 days caused a significant increase in the difference between the active and inactive periods of BP with an extreme dipper type of BP, while proteinuria and renal tissue injury were not observed. Interestingly, HSD feeding for 10 weeks developed hypertension with a non-dipper pattern of BP, which was associated with obvious proteinuria and renal tissue injury. Four weeks after switching to an NSD, BP and proteinuria were significantly decreased, and the BP circadian rhythm returned to the normal dipper pattern. These data suggest that the non-dipper pattern of BP is associated with the progression of renal injury during the development of salt-dependent hypertension.
- Subjects
BLOOD pressure; HIGH-salt diet; RATS; WOUNDS &; injuries; HYPERTENSION; SALT-free diet
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 6, p2248
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21062248