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- Title
Ultrasonic Synthesis and Preliminary Evaluation of Anticoronaviral Activity of 6,7-Dimethoxy-4-(4-(4-methoxyphenyl)piperazin-1-yl)-1-methylquinolin-1-ium Iodide.
- Authors
Vasilev, Aleksey A.; Grozdanov, Peter P.; Nikolova, Ivanka; Lozanov, Valentin S.; Kandinska, Meglena I.
- Abstract
Quinoline scaffold is one of the most intensively utilized pharmacophores in drug design because of the variety of activities demonstrated by different quinoline-based therapeutics or drug-candidates. Herein, we describe an environmentally tolerant two-step procedure as a convenient synthetic approach to novel chloroquine and hydroxychloroquine analogues. The structures of the newly synthesized compounds are estimated by 1H NMR, 13C NMR, LC-MS spectrometry and IR spectroscopy.
- Subjects
ULTRASONICS; CHLOROQUINE; DRUG design; IODIDES; HYDROXYCHLOROQUINE
- Publication
Molbank, 2022, Vol 2022, Issue 3, pM1400
- ISSN
1422-8599
- Publication type
Article
- DOI
10.3390/M1400