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- Title
Lipoprotein-Associated Phospholipase A<sub>2</sub> Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome.
- Authors
Hyemoon Chung; Hyuck Moon Kwon; Jong-Youn Kim; Young Won Yoon; Jihyuk Rhee; Eui-Young Choi; Pil-Ki Min; Bum-Kee Hong; Se-Joong Rim; Ji Hyun Yoon; Sung-Joo Lee; Jong-Kwan Park; Myung-Hyun Kim; Minhee Jo; Jeong-Hee Yang; Byoung Kwon Lee
- Abstract
Purpose: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) binds to low-density lipoprotein. The levels of Lp-PLA2 reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. Materials and Methods: We classified 226 study participants into three groups: patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group). Results: Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA2 levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA2 to the ACS model significantly increased the global χ² value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA2 was 0.624 (p=0.004). The addition of Lp-PLA2 level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error: 0.0142) and improved the ability to diagnose ACS. Conclusion: Lp-PLA2 levels are related to plaque stability and might be a diagnostic biomarker for ACS.
- Subjects
ACUTE coronary syndrome; PHOSPHOLIPASE A2; BIOMARKERS; BLOOD lipoproteins; LOW density lipoproteins; C-reactive protein; DIAGNOSIS; PATIENTS
- Publication
Yonsei Medical Journal, 2014, Vol 55, Issue 6, p1507
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2014.55.6.1507